Industry News

Dental Groups Pledge Funds to Manchester Bombing Victims

Dental Groups Pledge Funds to Manchester Bombing Victims

26 May 2017

As dentists from across the United Kingdom attend the British Dental Conference and Exhibition, May...

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April 2017

Composite Vs. Porcelain’s:
What You Need To Know

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March 2017

Digital Marketing for Dentists

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February 2017

Traumatic Dental Injuries: Emergency Assessment And Treatment

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January 2017

Buffered Anesthesia: Efficiency & Profitability

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Recent Issues

May 2017

Solving Aesthetic Challenges From Trauma-Based Injuries




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April 2017

New Trends in Endodontics and Treatment Planning




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Taste Genes Predict Tooth Decay

Dental caries is a highly prevalent disease that is disproportionately distributed in the population. Caries occurrence and progression is known to be influenced by a complex interplay of both environmental and genetic factors, with numerous contributing factors having been identified, including bacterial flora, dietary habits, fluoride exposure, oral hygiene, salivary flow, salivary composition, and tooth structure. Previous reports have characterized the influence of the genetic variation on taste preferences and dietary habits.

In an article published in the Journal of Dental Research titled “Taste Genes Associated with Dental Caries” lead researcher Steven Wendell and researchers Melissa Brown, Margaret Cooper, Rebecca DeSensi, Mary Marazita, Xiaojing Wang and Robert Weyant, all from the University of Pittsburgh; and Richard Crout and Daniel McNeil from West Virginia University, hypothesized that genetic variation in taste pathway genes (TAS2R38, TAS1R2, GNAT3) may be associated with dental caries risk and/or protection.

In this study, families were recruited by the Center for Oral Health Research in Appalachia (COHRA) for collection of biological samples, demographic data and clinical assessment of oral health including caries scores. Multiple single nucleotide polymorphism (SNP) assays for each gene were performed and analyzed using transmission disequilibrium test (TDT) analysis (FBAT software) for three dentition groups: primary, mixed, and permanent. Statistically significant associations were seen in TAS2R38 and TAS1R2 for caries risk and/or protection.

“This work is significant in that it identifies key genes that may explain the susceptibilities of some patients to tooth decay,” said JDR Editor-in-Chief William Giannobile. “Although an early study, this breakthrough on taste pathways and genes demonstrates how patient preferences that are genetically predetermined may put patients at risk for disease.”

 

The Wednesday Watch

Exclusive Interview: Dr. Thomas McClammy

Exclusive Interview: Dr. Thomas McClammy

24 May 2017

Dr. Tom McClammy speaks to us fresh from the stage after his GentleWave presentation at...

Technique of the Week

e-Prescribing with XLDent

e-Prescribing with XLDent

29 March 2017

Drs. David Andersen and Lora Nelson explain how easy e-Prescribing...

Technology Today

Show Me the Way

Show Me the Way

02 May 2017

This year’s International Dental Show did not disappoint: 155,000 participants from 157 countries attended,...

Implants Today

Narrow-Body  Dental Implants

Narrow-Body Dental Implants

02 May 2017

As the multibillion-dollar market for dental implants grows, many new companies are entering the...

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