Rowpar Pharmaceuticals’ CloSYS Ultra Sensitive Oral Rinse reduced SARS-CoV-2 by up to 98.4% within 30 seconds in in vitro laboratory analysis without the use of any harsh chemicals like alcohol, hydrogen peroxide, or povidone iodine, according to the company.
MRI Global, an independent laboratory in Kansas City that is accredited to test highly infectious viruses like SARS-CoV-2, conducted the study. Microbac Laboratories, a second independent and accredited lab in Sterling, Virginia, provided similar results.
These trials did not include tests of the oral cavity. Based on these results, though, Rowpar has launched additional studies to determine whether its CloSYS over-the-counter products can help reduce the transmission of the novel coronavirus from one person to another.
“We know that the COVID-19 virus can be transmitted from person to person through spray droplets from the mouth, so this is an important first step in determining whether our oral care products can make a significant impact in reducing the chances of becoming ill or infecting others,” said Rowpar Pharmaceuticals CEO Jim Ratcliff.
“There is a lot more to learn as we follow the science, but it’s a very positive start for our rinse formula,” said Ratcliff.
There is no evidence that inactivating the COVID-19 virus in the mouth will impact disease transmission, the company said, but the studies reinforce the antimicrobial strength of CloSYS products. Clinical trials in progress at the University of California San Francisco are evaluating whether oral rinses can reduce the viral load in the mouth, which may in turn reduce disease transmission.
All CloSYS products include a proprietary formula with Clorastan, the trade name for stabilized chlorine dioxide, which the company says is a safe and effective oxidant long recognized for its antimicrobial, disinfecting, and sanitizing properties.
The CloSYS formula is naturally activated by acids in saliva. Once released, Clorastan disrupts and penetrates dental biofilm, killing the microbial pathogens living within and inhibiting their regrowth, Rowpar said.
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