A University of Louisville (UofL) scientist has found a way to prevent inflammation and bone loss surrounding the teeth by blocking a natural signaling pathway of the enzyme glycogen synthase kinase 3 beta (GSK3β), which plays an important role in directing the immune response. The discovery of David Scott, PhD, and his team was recently published online in the journal Molecular Medicine. The finding not only has implications in preventing periodontal disease, but also may have relevance to other chronic inflammatory diseases. Since GSK3β is involved in multiple inflammatory signaling pathways, it is associated with a number of diseases and also is being tested by scientists for its impact in Alzheimer’s disease, type II diabetes, and some forms of cancer, to name a few. “The traditional approach to dealing with periodontal disease is to prevent plaque from forming at the gum-line or prevent the consequences of periodontal disease progression,” Dr. Scott said. “Our approach manipulates a natural mechanism within our bodies to prevent inflammation and subsequent degradation when exposed to the bacterium Porphyromonas gingivalis.” GSK3β is known to facilitate the inflammation that occurs during bacterial infections, so blocking this enzyme from completing its normal function by using the GSK3-specific inhibitor, SB-216763, stopped the inflammation process and subsequent bone loss induced by the key periodontal pathogen, P gingivalis, Dr. Scott said. The next step for Dr. Scott and his team is to determine whether SB-216763 has any side effects or whether they need to search for a different inhibitor of GSK3β.
(Source: UofL news release, September 11, 2012)
