Root canals always face the risks of contamination from bacteria, viruses, and yeasts. To protect patients from these potential infections, an injectable antimicrobial gel developed by visiting assistant professor Ghaeth H. Yassen, BDS, MSD, PhD, of the Indiana University School of Dentistry could more effectively disinfect teeth during treatment.
“I wanted to create a gel that provides sustained antimicrobial properties even when it is removed. I also wanted it to have minimal toxic effect on stem cells and not cause tooth discoloration,” Yassen said. “Creating an antimicrobial space is especially important during clinical regenerative endodontic procedures.”
The gel has advantages over calcium hydroxide, which is widely used as an antibacterial agent, and other traditional medications, Yassen said.
“The gel offers extended and significantly longer residual antibacterial properties, which has been proven in papers published in the Journal of Endodontics and the International Endodontic Journal,” said Yassen. “It is biocompatible, and it contains a low concentration of antimicrobial elements.”
Yassen next will optimize a version of the gel that is opaque to x-rays and other radiation, so dental professionals can track it within the root canal system. He has disclosed the gel to the Indiana University Innovation and Commercialization Office, which is now seeking commercial partners to continue development and bring the gel to the marketplace.
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